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Women have a higher prevalence of melasma compared to men: approximately 9% of individuals affected are men, while 89% are women

Khoury, S

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Look for activated charcoal made from coconut shells or identified wood species that have ultra-fine grains

Hypoxia not only manifests as the direct effect of insufficient oxygen supply to tissues, but the microenvironmental disturbances it triggers are often accompanied by significant oxidative stress, constituting a core factor exacerbating pathological damage [5]