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The FDA's 2024 review discussed free-base and acetate forms but did not set a standard acetic-acid mixing instruction

Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is considered as effective as intramuscular administration for correcting anemia and neurologic symptoms Despite many studies suggesting oral administration of vitamin B 12 to be easy, effective and less costly than intramuscular administration, debate surrounds the effectiveness of the oral route

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Several drugs, including colchicine, have been reported to reduce the absorption of methylcobalamin, vitamin B12