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Trivedi MS, et al
Single doses of 42, 140, 420 and 1260 mg intravenously were well tolerated and showed dose-proportional, linear pharmacokinetics, with the half-life increasing with the dose Ruff et al., 2010
The early signs you notice after starting B12 treatment indicate that your body is responding to the therapy
The researchers adjusted for a variety of other factors, including serum cholesterol, lifestyle, and body mass index
In addition, no covariate (in particular dosage) was incorporated into the E max model, showing there was no significant dose-dependence from l-carnitine efficacy on BMI in T2DM patients
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