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We recently reported that low nanomolar concentration of PregS induce a delayed-onset increase of the neuronal response to NMDA and trafficking of NMDAR to the cell surface through an intracellular ([Ca 2+ ]i)-dependent mechanism (47) (Figure 2)

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It is also reported that SGLT2 inhibitors improve -cell mass and function via similar mechanisms as DPP-4 inhibitors, although the mechanism of glucose-lowering effect is totally different 9,10,30