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For the BBB in vitro model, mouse BALB/c brain endothelioma cell line b.End3 was used (CRL.2299, ATCC)

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In one of the clinical trials, SELECT, patients who were treated with semaglutide experienced a 20-28% reduction in major adverse cardiovascular events (MACE) nonfatal myocardial infarction (MI), nonfatal stroke, and cardiovascular death