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Cell-based assay for detecting the EC50 of peptide hormones The activation of GLP-1R induced by synthetic peptide hormones including GLP-1(737), EX4(139), GLP-1(937) and EX4(339) was evaluated using special AD293 cells that stably expressed human GLP-1R and NanoLuc luciferase under control of a cAMP response element (CRE
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Increased heart rate was also reported in trial participants
Gastrointestinal effects Nausea, constipation , diarrhea , and reduced appetite are the most common side effects with both medications
Nogueira, J
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