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Unlike -KG, abnormal accumulation of succinate and fumarate in tumor tissues represses PHD, thus reducing HIF1 hydrolysis, suppressing demethylation of DNA and histones, and promoting the occurrence and development of tumors (Cavalli and Heard, 2019)

GLP-1 medications have emerged as a valuable addition to the arsenal of treatments for type 2 diabetes, offering benefits such as improved blood sugar control, weight loss, and cardiovascular protection

Bresin A, Iacoangeli A, Risuleo G, Scarsella G

Those with pre-existing mental health conditions may require closer monitoring and coordinated care between GP, diabetes specialists, and mental health professionals