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The neuroprotective benefit may stem from GLP-1s role in insulin signaling within the brain, where insulin resistance is a recognized early feature of Alzheimers pathophysiology
When cirrhosis develops, a state of hepatic GH resistance ensues resulting in high GH and low IGF-I levels (125) ( Figure 1E )
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Produced in the intestines, GLP-1 supports stable blood sugar levels, slows digestion, promotes satiety (feeling of fullness), and prevents excess glucose production by the liver
The medication may be allowed to reach room temperature before administration if stored under refrigeration, as cold injections may be more painful and could potentially affect absorption kinetics
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