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doi: 10.1196/annals.1447.049 47 HirotaKDuarteJHVeldhoenMHornsbyELiYCuaDJet al

group, the Sarcopenia Definition and Outcomes Consortium (SDOC), went further: pooling data from more than 18,000 participants across eight epidemiologic studies and six randomized trials, SDOC found that DXA-measured lean mass did not predict falls, fractures, mobility limitation, or mortality once other factors were accounted for

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CBS deficiency led to markedly homocysteine accumulation and severely decreased levels of cystathionine and cysteine, which was due to impaired homocysteine removal through the transsulfuration pathway [32]