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Cell (2017) 171:27385
It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation
Claims with weak, preliminary, preclinical, or unsupported evidence are identified as such rather than presented as established medical benefit
In addition to downregulation of injury and inflammation-related pathways, GSEA also revealed suppression of adipogenesis-related pathways in the liver of GPR146-deficient mice, suggesting that GPR146 may promote hepatic steatosis via PPAR-mediated transcriptional programs (Fig
