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2.1 Study design In this prospective, double-blind, cross-over interventional study, patients were randomized in balanced blocks (1:1) into two groups: Sequence 1, HA-first, received the control product (containing only hyaluronic acid 0.2%) for 4 weeks, followed by a 1-week washout, and then the experimental product (hyaluronic acid 0.2% + butyroyl glutathione 0.4%) for 4 weeks

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TABLE 3 Major inhibitors of ferroptosis