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1c) of acid-ethanol extracts of rat gastric and ileal mucosa identified proglucagon, GLP-1, and GLP-2 fragments consistent with PC1/3 cleavage sites after trypsin, Lys-C, chymotrypsin, and Glu-C digestion

Cell Physiol Biochem 44:763777

These symptoms are primarily due to the mode of action of GLP-1 RAs on the gut, as a GLP-1 may directly or indirectly regulate electrolyte and fluid homeostasis by influencing feeding and drinking behavior as well as electrolyte transport in the kidneys and gastrointestinal tract [25]

If diarrhea is explosive or forceful, it can cause small tears in the anal lining, leading to more discomfort