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The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation
It is needed for: Methylation B12 is cofactor in the process that synthesises the nearly universal methyldonor in the body: S-adenosyl-methionine
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[16] [121] Investigations into the intestinal absorption of B 12 confirm that the upper limit of absorption per single oral dose is about 1.5 g, with 50% efficiency
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