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By reducing intracellular sodium and Ca 2+ overload, SGLT2i preserve ionic equilibrium in cardiomyocytes, thereby mitigating ischaemic injury [187]

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The cells are characteristically quite large with abundant eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli

Extended 12-Week Protocol (Optional) Note: The 12-week extension reaches higher daily doses (10001300 mcg) explored in performance and metabolic research