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Almutairi M, Gopal K, Greenwell AA, Young A, Gill R, Aburasayn H, Al Batran R, Chahade JJ, Gandhi M, Eaton F

Various hormones and metabolic fuels affect hypothalamic malonyl-CoA levels and malonyl-CoA is considered a key satiety inducing signal in the brain

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The vascular-endothelial hypothesis posits improvements in endothelial function, nitric-oxide signaling, and microvascular perfusion, yet these vascular signatures vary dramatically between tissues and do not fully account for neuroprotective or immunomodulatory patterns