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The potential main mechanism responsible for SGLT2-i reno-protective properties probably resides in TGF activation and glomerular hyperfiltration reduction
The result is a designer molecule whose pharmacokinetics are matched to clinical needs, enabling weekly dosing and a predictable therapeutic window with manageable tolerability across diverse patient populations
There are a few rare additional side effects: Severe allergic reactions have been reported with GLP-1 agonists
Talk often with your healthcare provider about any side effects that come up
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