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According to the same PMC/NIH review, topical GHK-Cu applied to thigh skin over 12 weeks improved collagen production in 70% of participants, compared with 50% for a vitamin C cream and 40% for retinoic acid in the same study a comparison that helped cement GHK-Cus reputation as a serious subject of dermatological research

Any one of these alone leaves two of three components unconfirmed

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Between uses, the vial septum should be protected from contamination, and proper aseptic technique should be used for each withdrawal

GST polymorphisms may play a role in the efficacy of NAC