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Topical Wound Applications in Preclinical and Clinical Settings In animal models of open and ischemic wounds, GHK-Cucontaining preparations appeared to align with faster closure metrics, earlier granulation, and more prominent neovascular features than control comparators

The collagen remodeling cycle completes its first full pass, and the cumulative effect of new fiber synthesis becomes visible as improved firmness, reduced sagging in the lower face and neck, and a measurable difference in skin density

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37 DateI.TakagiN.TakagiK.TanonakaK.FunakoshiH.MatsumotoK.et al (2006)