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Binding of the ligand (GLP-1) or its analog on the extracellular side of the protein induces conformational changes that are sensed by the G-proteins on the cytoplasmic face - initiating a signaling cascade (see Figure 3 a and b)

And it can cause lower abdominal pain, bloating, and other symptoms

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The condition causes repeated breathing interruptions during sleep, leading to oxygen desaturation, frequent awakenings, and severely degraded sleep quality

When you stop treatment, these processes normalize, but your baseline metabolic rate does not automatically drop below where it started