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The mechanism is hypothesized to be similar to the intracellular process that leads to neuronal damage in Alzheimers disease

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One user encourages patience: "Skin tightens over time give it a year and see how you look." anonymous Slower weight loss may allow more time for skin adaptation: "Ive been low and slow my skin is a little saggy when I lose weight then slowly gets tighter." Stunning_Jeweler8122 Others report long-term improvement: "My stomach ended up fine it took 2 years though." monoDioxide Clinical guidance suggests skin remodelling can continue for months to years , but full retraction is not guaranteed

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