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One depends on the GLP-1 receptor mediated action with inotropic, glucose uptake stimulating, and ischemic preconditioning effects, and secondly that the GLP-1 receptor independent pathway causes vasodilatation that is mediated by nitric oxide 5
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Abstract Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two incretins that bind to their respective receptors and activate the downstream signaling in various tissues and organs
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