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Nat Rev Endocrinol 8:728742 Rosenstock J, Raccah D, Koranyi L et al (2013) Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X)

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the REWIND trial showed CV benefit including in primary prevention populations

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Medical conditions like anaemia, hypothyroidism and polycystic ovarian syndrome can also increase pigmentation

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If medicines that normally require food are consumed during a fast, their effects can become exaggerated or dangerously unpredictable.In cases like Shefalis, where injections and pills were taken during a fast, even a routine dosage could have contributed to the body going into shock or developing cardiac symptoms

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