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Tirzepatide or alternative medications can be restarted if lifestyle measures prove insufficient, and there is no penalty for resuming treatment when medically appropriate

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However, when combined with GLP-1 activity to keep glucose in check, the glucagon component drives increased energy expenditure through thermogenesis, enhanced fat oxidation and breakdown, improved metabolic rate, and potential additional central appetite regulation through pathways that neither GLP-1 nor GIP can access alone