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Before Starting Semaglutide (if already on levothyroxine), discuss: Your current thyroid function status and most recent TSH results How well-controlled your hypothyroidism has been and any recent dose adjustments Your weight loss goals and how they might affect thyroid hormone requirements The monitoring schedule for thyroid function during semaglutide therapy Specific timing strategies for medication administration, such as: If Already Taking Both Medications , address: Any new symptoms that might indicate thyroid dysfunction Changes in weight and whether levothyroxine dose adjustment is needed Gastrointestinal side effects and their impact on medication adherence Results of recent laboratory tests and what they mean for your treatment plan Your current medication timing routine and any challenges with adherence Be prepared to provide a complete medication list , including prescription medications, over-the-counter drugs, vitamins, and supplements