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In the nucleus, Nrf2 interacts with small Maf proteins (sMAF) and binds to antioxidant response elements (ARE), promoting the transcription of downstream antioxidant genes (Yan et al., 2023)

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Astrocytes, in contrast, play a dual role: while their dysfunction can promote oxidative stress and calcium dysregulation, they also retain protective mechanisms such as the Nrf2-GPX4 antioxidant pathway, representing a potential therapeutic target