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introduced mRNA-lipid nanoparticles that reprogrammed macrophages in situ into CAR-Ms, restoring immune clearance against multidrug-resistant bacteria in septic mice (Tang et al., 2024)

Finally, cells were resuspended in 100 l of fresh culture medium and analyzed on a Thermo Fisher Attune flow cytometer for Pacific Blue or FITC and 7-AAD staining to assess apoptosis and lytic cell death

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The primary endpointchange in Clinical Dementia Rating Sum of Boxes (CDR-SB)showed no significant difference between groups

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