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Angiotensin II (Ang II), a key component of RAAS, is known to stimulate the production of ROS, particularly in vascular smooth muscle cells and endothelial cells [80]
Tests were carried out as described by the manufacturers instruction
However, the potential side effects of NRF2 activators and ferroptosis inhibitors have not been thoroughly evaluated
This is one area where the triple agonist approach clearly outperforms dual agonism
Leite Silva ABR, Gonalves de Oliveira RW, Digenes GP, de Castro Aguiar MF, Sallem CC, Lima MPP, de Albuquerque Filho LB, Peixoto de Medeiros SD, et al
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