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Interestingly, reproductive responses were partially different in the PCOS model of preserved ovulation, since treatment of PNA mice with a low dose of GLP1/E was capable to elevate LH levels and reversed, to a large extent, the ovarian cycle irregularities observed in PNA mice treated with vehicle

& Morales, P

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It acts as a retrograde signal from mitochondria to the cell nucleus, activating the AMPK pathway, which is the master regulator of cellular energy balance