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Radiotherapy and certain chemotherapy drugs evoke profound anti-tumor immunity by inducing immunologic cell death that release tumor-associated antigens together with numerous pro-immunological factors, leading to priming of cytotoxic CD8+ T cells and enhancing the cytotoxicity of macrophages and natural killer cells

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Both aspartate and glutamate side chains contribute acidic character to the molecule, while the indole ring of the N-terminal Trp provides a convenient UV chromophore near 280 nm for spectrophotometric identity checks and HPLC detection