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10.1056/NEJMc1913157 Summary Keywords subcutaneous semaglutide, dulaglutide, extended-release exenatide, type 2 diabetes, UKPDS OM, cost-utility analysis, once-weekly GLP-1 receptor agonist Citation Hu S, Wang S, Qi C, Gu S, Shi C, Mao L and Fan G (2022) Cost-Utility Analysis of Once-Weekly Semaglutide, Dulaglutide, and Exenatide for Type 2 Diabetes Patients Receiving Metformin-Based Background Therapy in China
This conjugation reduces their reactivity and targets them for elimination via the bile and urine
The semaglutide molecule will still undergo gradual breakdown through hydrolysis and oxidation, just as it would in any aqueous solution
