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By covalent (albiglutide, dulaglutide) or no-covalent (semaglutide) coupling to larger molecules with slow clearance, analogs with even more prolonged activity have been produced so that there are now several once-weekly agonists on the market

These compounds, which include synthetic xenoestrogens, phytoestrogens, and metalloestrogens, can disrupt reproductive physiology and developmental processes in domestic animals

185 In addition, aptamers are widely used in drug delivery, clinical diagnostics, and biosensing

A separate dosage article can cover protocols, administration routes, and clinician-guided use in more detail