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Chronic stress and inflammatory stimuli promote microglial activation, leading to sustained release of pro-inflammatory cytokines, reactive oxygen and nitrogen species, and excitotoxic mediators that disrupt synaptic function and neuronal integrity ( Neuroinflammation also interacts bidirectionally with dysregulation of the hypothalamicpituitaryadrenal (HPA) axis
Andreeff, M, Drach J, Zhao S, Consoli U, Escudier S, Sanchez-Williams G, Liu Y, Goodacre A, Drach D, Dunne C, Tafuri A, Estey E, Deisseroth A
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