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AA is involved in several non-oxidant processes, including epigenetic regulation of TH expression and participation in catecholamine synthesis steps, specifically DA and norepinephrine 61
Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population
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