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NEW PRODUCT DEVELOPMENT The Liraglutide and Semaglutide Market Trends in innovation indicate that approximately 67% of pharmaceutical companies are focusing on next-generation GLP-1 receptor agonists with improved efficacy and safety profiles

458,459,460 Metformin also promotes re-esterification of free fatty acids and inhibits lipolysis, which may then indirectly increase insulin sensitivity by reducing lipotoxicity in adipose tissues