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B12 injections are contraindicated for individuals with Lebers hereditary optic neuropathy, severe kidney disease, known cobalt or cobalamin allergy, and polycythemia vera

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Clinical practice has shown that in a substantial number of patients seen in a tertiary care setting, injection frequency cannot be reduced after the initial loading regimen

Clinically relevant to humans To evaluate the materials effectiveness in promoting cartilage growth, the investigators tested it in sheep with cartilage defects in the stifle joint, a complex joint in the hind limbs similar to the human knee

All of them are not sold by prescription