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The overall pattern is consistent: most gastrointestinal side effects peak during dose escalation, diminish within weeks, and become minimal at stable maintenance doses
Biochim Biophys Acta 1813:13331350
Animal research, including a study in aged rhesus monkeys, found that Epitalon administration significantly stimulated evening melatonin synthesis in older animals, normalizing a circadian rhythm that typically deteriorates with age
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