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Increased oxidative stress, inflammation and lipotoxicity associated with hyperglycaemia and insulin resistance potentially impair vascular endothelial function and increase endothelial permeability, leading to the penetration of glycated and oxidized low-density lipoprotein (LDL) cholesterol into the endothelium, i.e., initiation of atherosclerosis

The report also notes that the U.S

Baseline labs should include serum copper, ceruloplasmin, 24-hour urine copper, and a comprehensive metabolic panel

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