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In the fasting group, no pre-dose meal was served

In the colon, they inhibit circular muscle contractions, slowing the passage of food

At the mRNA level, Bax and Bad significantly increased by 1.9-fold and 1.4-fold (log2 scale), respectively, in the DZN-treated group compared to the control group, and Bcl2 decreased by 0.6-fold (log2 scale) (Fig

In conclusion, our findings indicate that metformin may alleviate OA pain and partially attenuate the pathological changes associated with OA, suggesting a potential protective role

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