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Another compound that was identified as potent BACH1-inhibitor was the phytocannabinoid cannabidiol (CBD), which induces nuclear export and degradation of the transcription factor ( In vitro models have confirmed CBDs antioxidant and anti-inflammatory properties, acting through HMOX-1 and inducing the downregulation of pro-inflammatory cytokines (Juknat et al., 2016

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The 2mg starting dose was well tolerated in the trial, with gastrointestinal effects -- nausea, diarrhea -- most common at higher doses