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Persistent opioid use triggers immune activation within the brain, leading to microglial proliferation and the release of pro-inflammatory cytokines
The company has been in business since 2019
Silicon dioxide - Flow agent
44 Due to these promising results, as well as its established cardiovascular safety, 42,45 investigational interest around this agent is intense, with multiple randomized trials exploring its effects on liver fibrosis and steatosis of diabetic and nondiabetic patients, when administered alone, in combination or in comparison with other agents, such as empagliflozin (on diabetics-NCT04639414), efinopegdutide (on diabetics and non-diabetics-NCT04944992), cilofexor and firsocostat (on diabetics and non-diabetics-NCT04971785)
Headache, chest discomfort, weakness, runny nose, or abnormal sweating are less common
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