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The loss of DJ-1-mediated maintenance of the transsulfuration pathway could render microglia more vulnerable to ferroptotic damage, thereby linking its classical cytoprotective role in redox homeostasis directly to the emerging pathway of ferroptosis in neurodegeneration

GSH is synthesiszed via two ATP-dependent processes that are catalysed by -Glu-Cys synthetase (GSH1) and GSH synthetase (GSH2), and it is mostly degraded by -Glutamyl transpeptidases (-GT), which split GSH into cysteinyl-glycine (Cys-Gly) and Glu residue

Treatment of men with central hypogonadism: alternatives for testosterone replacement therapy

10.1016/j.bbadis.2023.167014 43 HanK.LiJ.YinS.HuH.ZhaoC

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