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Such GPX4-independent surveillance pathways are often mediated by enzymes that generate metabolites with radical-trapping antioxidant (RTA) activity, including ferroptosis suppressor protein 1 (FSP1), dihydroorotate dehydrogenase (DHODH), and GTP cyclohydrolase-1 (GCH1), etc 10,14,15,16

VITATOPS Trial Study Group