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Potential implications for insurers Insurers may want to consider the implications of AOMs for their business: Review trend assumptions to identify whether changes are needed Consider new lapse risks Assess how AOMs might affect underwriting and claims Establish processes to keep on top of this fast-moving space Reviewing mortality improvement assumptions An insurer's current mortality trend assumptions likely include anticipated improvements from drivers such as medical advances

Supplementary information Supplementary Sections 15: 1

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Beyond Month 6: Maintenance Most patients continue at 2.4 milligrams weekly through month 12, when full clinical trial endpoints are typically reached

Tsilou ET, Rubin BI, Reed G, Caruso RC, Iwata F, Balog J, Gahl WA, Kaiser-Kupfer MI (2006) Nephropathic cystinosis: posterior segment manifestations and effects of cysteamine therapy