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To resolve the complex crosstalk among these pathways, machine-learning frameworks built on PANoptosis-related risk scores (PRS) comprised of six key hub genes (YWHAH, PRKACB, PSMB9, FAS, GZMA, and CASP1) have revealed extensive molecular co-activation within tubular and interstitial segments, strongly predicting eGFR decline, serum creatinine elevation, and local immune cell recruitment (209)

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