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This additive effect on energy expenditure is why the retatrutide dosage range studied (112mg weekly) produced weight loss outcomes that exceeded all prior incretin-class compounds in head-to-head timelines
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Lancet 368(9548):16961705 Muskiet MHA, Tonneijck L, Smits MM, Van Baar MJB, Kramer MHH, Hoorn EJ et al (2017) GLP-1 and the kidney: From physiology to pharmacology and outcomes in diabetes
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