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Both peptides are administered intranasally at doses of 300-900 g/day, bypassing first-pass metabolism and potentially achieving direct brain delivery through the nose
Leutgeb, J
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Secondly, the redox status of the cell affects many of the enzymes in one-carbon metabolism including MATI, MATIII, MS, BHMT, as well as CBS and GCS in the transsulfuration pathway, and therefore one cannot evaluate GSH metabolism without including the methionine and folate cycles
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