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It represents a breakthrough in pharmaceutical design that solved a major challenge in developing GLP-1 medications

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18 letter to the agency, the state officials maintained that supply shortages and high costs have created opportunities for wrongdoers to cash in and endanger consumers. In particular, they pointed to counterfeiters, online retailers selling active ingredients without requiring a prescription, and some compound pharmacies that cut corners in preparing custom-made versions of the drugs

As the active ingredient in Mounjaro (approved May 2022 for type 2 diabetes) and Zepbound (approved November 2023 for chronic weight management, expanded December 2024 for obstructive sleep apnea), tirzepatide works by mimicking two natural hormones GLP-1 and GIP that regulate hunger, blood sugar, and metabolism

Some insurance plans cover brand-name Mounjaro or Zepbound with prior authorization, reducing out-of-pocket costs to $25 to $100 per month