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Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (Nos
Detoxification is a marathon, not a sprint
Importantly, mitochondrial DNA (mtDNA) mutations, which accumulate with age and HTN, perpetuate this dysfunction, rendering the vasculature more susceptible to oxidative injury
In mitochondrial muscle disease, however, both muscle and blood showed decreased NAD + levels 15,30 suggesting that blood is a valid source of redox-metabolite analysis in the context of pathology
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