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(n=706, 26 weeks) and the REDEFINE 1 cagrilintide-alone arm (n=302, 68 weeks)

Contact your healthcare provider if you experience: Severe or persistent gastrointestinal symptoms Whilst nausea, vomiting, and diarrhoea are common when starting Saxenda, symptoms that are severe, worsening, or not improving with dose stabilisation require assessment

When it fails : If constipation does not improve after 8 weeks at the same dose with adequate fiber and fluid intake, the hold alone is insufficient

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This creates a compounding problem