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Even a 20% relative increase in apixaban AUC from CYP3A4 inhibition would raise the projected major bleeding rate to approximately 2.6% per year, still lower than warfarin in ARISTOTLE but meaningfully above baseline apixaban risk
also designated PtdIns-4,5-P 2 ) is not only a substrate for the PLC family enzymes, whose actions lead to the release of DAG and IP 3 , but is also a substrate for a family of kinases that phosphorylate the membrane lipid on the 3-OH on inositol
Hard biomarker improvements (IGF-1, body composition) typically take 46 months and are modest in scale
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doi: 10.1136/bmj.291.6510.1693
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